Endocrine Abstracts

Background: Monosodium glutamate (MSG) use for food addictive have become quite alarming taken together with the huge reports of its toxic effects in the different organ of the body. Thus, this study demonstrates the therapeutic potentials of Mc on MSG-induced ovarian toxicity in female Wistar rats.Methods: A total of 28 female rats (weight=165±3g) were randomly assigned into 4 groups (A – D, n=7) and treated orally as follows: A – ...

Alzheimer’s disease (AD) development has a direct relationship with Brain-insulin resistance. Central in the pathology of AD are beta-amyloid and tau proteins associated with cognitive decline in the hippocampus. Allium sativum L. has been shown to have a neuroprotective effect. Thirty-two male Wistar rats (80-150 g) were assigned into A-D (n=8 each), and housed in standard plastic cages at 23± 1°C. Group A received saline, groups B and C were ad...

Cognitive impairment and neurodegeneration are a few hallmarks of brain insulin resistance, a core feature of Type 2 diabetes mellitus (T2DM). Using a Wistar rat model of a high-fat diet and streptozotocin-induced T2DM, we aimed to determine the potential of Vernonia amygdalina (VA) as a possible treatment for the accompanied neurodegenerative effects of this condition on hippocampal structure and function. T2DM adult rats were prepared by a combination of a high-fat diet and ...